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Co-evolution of transcriptional and post-translational cell-cycle regulation

✍ Scribed by Jensen, Lars Juhl; Jensen, Thomas Skøt; de Lichtenberg, Ulrik; Brunak, Søren; Bork, Peer

Book ID
109896209
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
634 KB
Volume
443
Category
Article
ISSN
0028-0836

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## Abstract PTEN is a critical tumor suppressor gene mutated frequently in various human cancers. Previous studies have showed that PTEN mRNA expression is down‐regulated by TGF‐β1 in various cell lines. In present study, we have found that TGF‐β1 down‐regulates PTEN mRNA and protein expression in