The methanol extract obtained from the fruits of Cassia fistula L. inhibited the 5-lipoxygenase catalysed formation of leukotriene B 4 in bovine polymorphonuclear leukocytes with an IC 50 value of 38 mg/mL. Also, lipid peroxidation in bovine brain phospholipid liposomes induced with 2,2'-azo-bis-(2-
CNS activities of Cassia fistula in mice
β Scribed by U. K. Mazumder; Malaya Gupta; Nandita Rath
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 71 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0951-418X
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β¦ Synopsis
The methanol extract of the seed of Cassia fistula was tested for different pharmacological actions in mice. The methanol extract (ME) of the seed significantly potentiated the sedative actions of sodium pentobarbitone, diazepam, meprobamate and chlorpromazine and was also found to potentiate significantly the analgesia induced by morphine and pethidine in a dose dependent manner. A depressant action of ME was also evident from the behavioural studies on mice.
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