✦ LIBER ✦

Clusters of identical new mutation in the evolutionary landscape

✍ Scribed by R. C. Woodruff; Haiying Hual; James N. Thompson

Publisher: Springer Netherlands
Year: 1996
Tongue: English
Weight: 887 KB
Volume: 98
Category: Article
ISSN: 0016-6707
DOI: 10.1007/bf00121363

No coin nor oath required. For personal study only.

✦ Synopsis

In contrast to the common assumption that each new mutant results from a unique, independent mutation event, clusters of identical premeiotic mutant alleles are common. Clusters can produce large numbers of related individuals carrying identical copies of the same new genetic change. By entering the gene pool in multiple copies at one time, clusters can influence fundamental processes of population genetics. Here we report evidence that clusters can increase the arrival and fixation probabilities and can lengthen the average time to extinction of new mutations. We also suggest it may be necessary to reconsider other fundamental elements of population genetic theory.

📜 SIMILAR VOLUMES

The role of the Pauli principle in three

The role of the Pauli principle in three-cluster systems composed of identical clusters

✍ Yu.A. Lashko; G.F. Filippov 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 241 KB

Within the microscopic model based on the algebraic version of the resonating group method the role of the Pauli principle in the formation of continuum wave function of nuclear systems composed of three identical s-clusters has been investigated. Emphasis is placed upon the study of the exchange ef

Shifts in the landscape of learning: New

Shifts in the landscape of learning: New challenges, new opportunities

✍ Mary-Jane Eisen 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 58 KB 👁 3 views

Inferring the functional effects of muta

Inferring the functional effects of mutation through clusters of mutations in homologous proteins

✍ Peng Yue; William F. Forrest; Joshua S. Kaminker; Scott Lohr; Zemin Zhang; Guy C 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB

Inferring functional consequences is a bottleneck in high-throughput cancer mutation discovery and genetic association studies. Most polymorphisms and germline mutations are unlikely to have functionally significant consequences. Most cancer somatic mutations do not contribute to tumorigenesis and a

An equipartition of energy theorem for w

An equipartition of energy theorem for weak solutions of evolutionary equations in Hilbert space: The Lagrange identity method

✍ Howard A Levine 📂 Article 📅 1977 🏛 Elsevier Science 🌐 English ⚖ 598 KB

Mutations of the adenomatous polyposis c

Mutations of the adenomatous polyposis coli gene in the mutation cluster region: Comparison of human pancreatic and colorectal cancers

✍ Kazuo Yashima; Shouji Nakamori; Yoshinori Murakami; Akio Yamaguchi; Kenshi Hayas 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 678 KB

## Abstract We analyzed the adenomatous polyposis coli (__APC__) tumorsuppressor gene as one of the possible genes mutated in human pancreatic carcinomas. DNAs from 39 surgical specimens were subjected to single‐strand conformation polymorphism analysis of polymerase chain reaction products and the

Operator derepressed mutations in the pr

Operator derepressed mutations in the proline utilisation gene cluster of Aspergillus nidulans

✍ Sophianopoulou, Vicky ;Suárez, Teresa ;Diallinas, George ;Scazzocchio, Claudio 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 697 KB

The proline utilisation gene cluster of Aspergillus nidulans can be repressed efficiently only when both repressing nitrogen and repressing carbon sources are present. We show that two cis-acting mutations in this cluster permit the efficient transcription of the prnB gene under repressing condition