Clustering and clinical diversity of adult T-cell leukemia/lymphoma associated with HTLV-I in a remote black population of French Guiana

✍ Scribed by Yann Gérard; Jean-François Lepere; Roger Pradinaud; Frank Joly; Louis Lepelletier; Michel Joubert; Dominique Sainte Marie; Renaud Mahieux; Abel Ureta Vidal; Dominique Larregain-Fournier; Francoise Valensi; Daniel Moynet; Guy De Thé; Bernard Guillemain; Jean-Paul Moreau; Antoine Gessain

• Book ID: 102870016
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: French
• Weight: 652 KB
• Volume: 60
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910600607

✦ Synopsis

An epidemiological study was performed in French Guiana (population I 15,000) to determine the prevalence and incidence of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell leukemia/lymphoma virus type I (HTLV-I). From January 1990 to December 1993, all suspected cases of ATL were enrolled in this study, and their clinical, epidemiological and immunovirological features were analyzed. Out of the 19 suspected cases, I 8 were considered as ATL associated with HTLV-I (8 acute forms, 8 lymphoma types and 2 smoldering cases). Before this study, only 2 ATL cases had been reported in French Guiana over a 10-year period. This demonstrates that the number of ATL cases is greatly under-estimated in most tropical HTLV-I endemic areas unless a specific disease search is performed. The mean age of the patients was 41 years. While HTLV-I antibodies were present in all cases, molecular studies demonstrated a clonal integration of HTLV-I in the tumoral cells in 7 cases out of the 9 tested. Fifteen patients died within a year