## Abstract MicroRNAs (mirs) are small noncoding RNA molecules (βΌ22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we
Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
β Scribed by Mydlarz, W.; Uemura, M.; Ahn, S.; Hennessey, P.; Chang, S.; Demokan, S.; Sun, W.; Shao, C.; Bishop, J.; Krosting, J.; Mambo, E.; Westra, W.; Ha, P.; Sidransky, D.; Califano, J.
- Book ID
- 121444155
- Publisher
- American Association for Cancer Research
- Year
- 2013
- Tongue
- English
- Weight
- 672 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1078-0432
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## Abstract Head and neck cancer is a challenging disease that is expected to account for greater than 500,000 new cases worldwide in 2008. Toxicity has impeded advances in chemotherapy and radiation for head and neck cancer, and the prognosis for patients with recurrent and/or metastatic disease r
The presence of gene amplification was determined in 66 fresh head-and-neck SCC specimens using a battery of 9 different probes. Amplification of at least one gene was found in I 2 samples (18%), of which 7 were amplified at multiple loci (58%). We observed amplifications for EGFR (10% of samples) a