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Clustered Sites of DNA Repair Synthesis during Early Nucleotide Excision Repair in Ultraviolet Light-Irradiated Quiescent Human Fibroblasts

✍ Scribed by Maria Svetlova; Lioudmila Solovjeva; Nadezhda Pleskach; Natalia Yartseva; Tatyana Yakovleva; Nikolai Tomilin; Philip Hanawalt


Book ID
115604276
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
919 KB
Volume
276
Category
Article
ISSN
0014-4827

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## Abstract Induction of the p21^WAF1^ protein (hereafter called p21) following genotoxic stress is known to inhibit proliferating cell nuclear antigen (PCNA)‐dependent DNA repair, downregulate apoptosis, and trigger a sustained growth‐arrested phenotype called accelerated senescence. Studies with