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Clozapine, atypical antipsychotics, and the benefits of fast-off D2dopamine receptor antagonism

โœ Scribed by Georges Vauquelin; Sophie Bostoen; Patrick Vanderheyden; Philip Seeman

Book ID
113021497
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
981 KB
Volume
385
Category
Article
ISSN
0028-1298

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Role of D1 and D2 dopamine receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine in rats
โœ Joseph H. Porter; Heidi F. Villanueva; John A. Rosecrans ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 139 KB ๐Ÿ‘ 2 views

The purpose of the present study was to assess the role of dopamine D 1 and D 2 receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine (CLZ). Two groups of rats were trained to discriminate either a moderate dose of clozapine (5.0 mg/kg) from vehicle or a high do