## Abstract Early somite mouse embryos were exposed in vitro to xylocaine (Lignocaine hydrochloride) to examine its effect on neural tube closure. When embryos were exposed to 2.4 ร 10^โ4^ mg/ml xylocaine for the entire 36โhour culture period, cephalic neural tube closure did not take place. When e
Closure of the neural tube in the cephalic region of the mouse embryo
โ Scribed by Geelen, Jan A. G. ;Langman, Jan
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 979 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0003-276X
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## Abstract The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds 240, including 205 representing specific genes, 30 for unidentified genes, and 9 multifactorial strains. These mutants identify genes needed for embryonic neural tube closure. Reports of 50 new NTD mutan