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Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7

โœ Scribed by Miles, John S.; Moss, Julie E.; Meehan, Richard R.; Wolf, C.Roland

Book ID
122056156
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
943 KB
Volume
7
Category
Article
ISSN
0888-7543

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Cytochrome P450 genes from the CYP2A, CYP2B, and C Y P 2 F subfamilies form a tight cluster which we have localized on the detailed physical map of human chromosome 19. The corresponding three gene subfamilies are also clustered in the mouse genome, on the region of chromosome 7 known to be syntenic

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We have studied the genetic linkage of two markers, the apolipoprotein C1 (APOC1) gene and a cytochrome P450 (CYP2A) gene, in relation to the gene for myotonic dystrophy (DM). A peak lod score of 9.29 at 2 cM was observed for APOC1-DM, with a lod score of 8.55 at 4 cM for CYP2A-DM. These two markers