Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
โ Scribed by Sunahara, Roger K.; Guan, Hong-Chang; O'Dowd, Brian F.; Seeman, Philip; Laurier, Lisanne G.; Ng, Gordon; George, Susan R.; Torchia, Joeseph; Van Tol, Hubert H. M.; Niznik, Hyman B.
- Book ID
- 109773792
- Publisher
- Nature Publishing Group
- Year
- 1991
- Tongue
- English
- Weight
- 912 KB
- Volume
- 350
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/350614a0
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๐ SIMILAR VOLUMES
Dopamine receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors, three different dopamine receptors (D1, D2, D3) have been cloned. Dopamine receptors are primary targets for drugs used in the treatment of psychomotor disorders such as Park
A series of 2,5-disubstituted-1H-pyrroles (4-18) has been prepared based on replacement of the amide of sultopride 1 by a pyrrole ring. Subsequent modification of the basic side chain gave compounds with high affinity for the dopamine D3 receptor. In addition, 12 and 17 were shown to be D3 antagonis