𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cloning and genomic characterization ofLST1: a new gene in the humanTNFregion

✍ Scribed by Ingrid Holzinger; Annegret Baey; Gerald Messer; Gerold Kick; Heinz Zwierzina; Elizabeth H. Weiss

Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
910 KB
Volume
42
Category
Article
ISSN
0093-7711

No coin nor oath required. For personal study only.

✦ Synopsis

The leucocyte specific transcript -1 (LST1) represents the human homolog of the mouse B144 transcript, encoded within the tumor necrosis factor (TNF) region of the human major histocompatibility complex class III interval. The gene is localized about 4 kilobases upstream of the lymphotoxin [3 gene. It spans a polymorphic genomic region encompassing the microsatellites TNFd and TNFe in intron 3 and a polymorphic Pvu II restriction site 260 base pairs downstream of the polyadenylation signal. Isolation of a full-length cDNA clone revealed that LST1 codes for IFN-7-inducible 800 nt transcripts, which are present in lymphoid tissues, T cells, macrophages, and histiocyte cell lines. The cDNA contains three long open reading frames (ORF) with the most likely ORF encoding a transmembrane protein. Its close linkage to the TNF genes and pattern of expression point toward a possible role for LST1 in the immune response.

πŸ“œ SIMILAR VOLUMES

Molecular cloning and characterization o
Molecular cloning and characterization of a new gene, Oocyte-G1
✍ Yong Zhang; Ji Wu πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 584 KB

## Abstract Oocytes are recognized as a source of regulatory molecules that influence follicular development through an array of actions on granulosa cells. Recently, more and more hormones and signaling molecules were identified during follicular developmental processes; however, the details about

Cloning, characterization and chromosoma
Cloning, characterization and chromosomal localization of the Sus scrofa SLC31A1 gene
✍ T. L. Harboe; L. R. Jensen; C. Hansen; P Horn; C. Bendixen; N. Tommerup; Z. TΓΌme πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 147 KB

## Summary Copper is an essential element necessary for normal function of numerous enzymes in all living organisms. Uptake of copper into the cell is thought to occur through the membrane protein, SLC31A1 (CTR1), which has been described in a variety of species including yeast, human and mouse. In

Cloning and characterization of PO22, a
Cloning and characterization of PO22, a pollen-expressed gene in alfalfa
✍ Yongzhong Wu; Xiao Qui; Sarah Du; Larry Erickson πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 318 KB

Genomic and cDNA clones have been isolated for a new gene (PO22) expressed in mature pollen of alfalfa. PO22 represents a single-or low-copy gene containing 4 introns, 2 transcriptional start sites, and 6oding for a predicted protein of 340 amino acids with no signal peptide and a coiled coil struct