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Cloning and expression of 5, 10-Methylenetetrahydrofolate reductase (MTHFR) gene

โœ Scribed by Guanghui Chen; Chenhui Zhang; Xiaoyu Zhang; Yanqing Zhu; Jian Tang; Zhaoheng Meng; Zhu Li


Book ID
105641183
Publisher
Science in China Press (SCP)
Year
1998
Tongue
English
Weight
622 KB
Volume
41
Category
Article
ISSN
1674-7305

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Valproic acid increases expression of me
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## Abstract Valproate (VPA) treatment in pregnancy leads to congenital anomalies, possibly by disrupting folate or homocysteine metabolism. Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate interconversion and homocysteine metabolism, we addressed the possibility that VPA