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Cloning and dosage compensation of the 6-phosphogluconate dehydrogenase gene (Pgd+) ofDrosophila melanogaster

โœ Scribed by Gutierrez, Anthony G. ;Christensen, Alan C. ;Manning, Jerry E. ;Lucchesi, John C.


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
683 KB
Volume
10
Category
Article
ISSN
0192-253X

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The molecular nature of lethal and semilethal mutations in the Pgd locus of D. melanogaster coding for 6-phosphogluconate dehydrogenase (6PGD) was studied. All the 11 mutations affect the structural gene of the Pgd locus: 3 semilethal mutations resulted in altered 6PGD molecules with decreased catal