Cloning and dosage compensation of the 6-phosphogluconate dehydrogenase gene (Pgd+) ofDrosophila melanogaster
โ Scribed by Gutierrez, Anthony G. ;Christensen, Alan C. ;Manning, Jerry E. ;Lucchesi, John C.
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 683 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0192-253X
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Drosophila melanogaster. The activity level is highest in early third instar larvae and declines to a lower, but relatively constant, level at all later stages of development. The enzyme is localized in the cytosolic portion of the cell. The A-isozymic form of 6-phosphogluconate dehydrogenase was pu
The molecular nature of lethal and semilethal mutations in the Pgd locus of D. melanogaster coding for 6-phosphogluconate dehydrogenase (6PGD) was studied. All the 11 mutations affect the structural gene of the Pgd locus: 3 semilethal mutations resulted in altered 6PGD molecules with decreased catal