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Cloning and characterization of the t(X;II) breakpoint from a leukemic cell line identify a new member of the forkhead gene family

✍ Scribed by Pauline Parry; Yalin Wei; Glen Evans

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 783 KB
Volume: 11
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870110203

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✦ Synopsis

Chromosome translocations involving I lq23 are associated with a number of different types of leukemia. These translocations fuse a gene encoding a putative transcription factor, HTRXI, to genes on other chromosomes. We report cloning and sequencing the t(X I I) breakpoint region from a cell line established from an infant with acute lymphocytic leukemia. The gene AFXI. on the X chromosome, is expressed in a variety of cell types. Sequence analysis indicates a high degree of homology between AFXl and the forkhead family of transcription factors. The high degree of identity within the forkhead region and the lack of homology outside that region suggest that AFXl represents a novel forkhead family member. It is predicted that a chimeric fusion protein with altered DNA binding activity will be the result of the translocation. Genes Chromosom Cancer I1:79-84 (1994).

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Translocations involving chromosome band I lq23 are found in both lymphoid and myeloid leukemias as well as in lymphomas, and we have recently reported that rearrangement of the M U gene is involved in these translocations. The chromosomes most frequently involved in reciprocal translocations includ