DNA rearrangements and altered transcripts of the MLL gene in a human T-all cell line karpas 45 with a t(X;II) (q13;q23) translocation

✍ Scribed by Dr. Norah R. McCabe; Magdalena Kipiniak; Hirofumi Kobayashi; Michael Thirman; Heidi Gill; Janet D. Rowley; Manuel O. Diaz

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 331 KB
• Volume: 9
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870090311

✦ Synopsis

Translocations involving chromosome band I lq23 are found in both lymphoid and myeloid leukemias as well as in lymphomas, and we have recently reported that rearrangement of the M U gene is involved in these translocations. The chromosomes most frequently involved in reciprocal translocations include chromosomes 4. 6, 9, and 19, and we and others have reported that chromosomes I, 2, 10, 15, 17, 18, 22, and X are also involved. In the cell line Karpas 45, which has a t ( X I I) (q I3;q23) translocation, we report here that the M U gene is rearranged and that there are two altered transcripts of M U that come from the der( I I) chromosome. Genes Chrom Cancer 9:22/-224 (1994).