Cloning and characterization of the t(5; 12) translocation breakpoint associated with chronic myelomonocytic leukemia (CMML)
โ Scribed by Todd Golub; George Barker; Michael Lovett; Gary Gilliland
- Book ID
- 113239967
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 116 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0145-2126
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A reciprocal chromosomal translocation, t( I 5; I7)(q22;q I I .2-I2), is characteristic of acute promyelocytic leukemia (APL) of French-American-British (FAB) subtype M3, and is not associated with any other human malignancy. The non-random pattern of the APL translocations suggests that specific ge
Using a series of yeast artificial chromosomes (YAC) from the 8p I I -I 2 chromosome region, we have analyzed a t(822) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both ca
## Abstract We report a case of __BCRโABL__โnegative atypical chronic myeloid leukemia (CML) with translocation t(4;22) (q12;q11.2) juxtaposing the breakpoint cluster region (__BCR__) and plateletโderived growth factor receptorโalpha (__PDGFRA__) genes. The patient was a 57โyearโold man with a hist