Clonidine-induced hyperphagia in monkeys: Evidence for α2-noradrenergic receptor mediation

✍ Scribed by R. Francis Schlemmer; Janice K. Elder; Regina C. Casper; John M. Davis

• Book ID: 104771129
• Publisher: Springer
• Year: 1981
• Tongue: English
• Weight: 192 KB
• Volume: 73
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00431113

✦ Synopsis

The mechanism of clonidine-induced hyperphagia and weight gain in monkeys was studied in 11 Stumptail macaques. Clonidine induced a significant increase in food intake over baseline levels and a significant weight gain after the 3-day treatment period. Both changes induced by clonidine were antagonized by the alpha 2-noradrenergic antagonist yohimbine, but not by prazosin, an alpha 1-noradrenergic antagonist. These results suggest that clonidine-induced hyperphagia and weight gain in monkeys are mediated through alpha 2-noradrenergic receptors.