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Clonal origin and trisomy of chromosome 15 in murine B-cell malignancies

✍ Scribed by Philip J. Fialkow; A. Lakshma Reddy; Jean I. Bryant

Publisher: John Wiley and Sons
Year: 1980
Tongue: French
Weight: 537 KB
Volume: 26
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910260512

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✦ Synopsis

Abstract

During the course of a multifaceted study of clonality in murine neoplasms we observed two B‐lymphoid malignancies. Results of studies with the X‐chromosome‐linked enzyme phosphoglycerate kinase strongly suggest that these tumors had a clonal origin. Each of them had trisomy 15. This chromosomal abnormality has been found consistently in many murine thymic neoplasms, and has been thought to be specific to tumors of thymic origin. However, the occurrence of trisomy 15 in each of the only two B‐cell malignancies thus far detected in our studies indicates that it may occur in Blymphoid progenitors as well.

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