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Clonal heterogeneity of HLA-B27 cellular allo-recognition. Delineation of immunodominant sites

✍ Scribed by Pedro Aparicio; Dolores Jaraquemada; Susana Rojo; José A. López De Castro


Book ID
102823113
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
647 KB
Volume
18
Category
Article
ISSN
0014-2980

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The molecular basis of the recognition of class-I HLA antigens by allo-reactive cytotoxic T lymphocytes (CTL) remains obscure. This article reviews our work in which HLA-B27-specific allo-reactive CTL clones were obtained and their fine specificity was analyzed with a panel of structurally defined H