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Clonal Analysis of Multiple Point Mutations in the N-rasGene in Patients with Acute Myeloid Leukemia

✍ Scribed by Kubo, Kazuaki ;Naoe, Tomoki ;Kiyoi, Hitoshi ;Fukutani, Hisashi ;Kato, Yoshiro ;Oguri, Takashi ;Yamamori, Shunji ;Akatsuka, Yoshiki ;Kodera, Yoshihisa ;Ohno, Ryuzo


Book ID
108579614
Publisher
Wiley (Blackwell Publishing)
Year
1993
Tongue
English
Weight
798 KB
Volume
84
Category
Article
ISSN
0910-5050

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Analysis of N-ras gene mutations in acut
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## Abstract N‐ras gene activation occurs via single base substitutions in codons 12, 13, and 61. We have developed a rapid screening method, termed allele specific restriction analysis (ASRA), for detection of N‐ras mutations at these three critical codons in acute myeloid leukemia (AML). Patient D