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Clonal analysis of cytotoxic T lymphocytes (CTL) against autologous melanoma

✍ Scribed by Peter Hersey; Malcolm MacDonald; Stephen Schibeci; Christine Burns

Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
903 KB
Volume
22
Category
Article
ISSN
0340-7004

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## Abstract Peripheral blood lymphocytes (PBL) from a melanoma (Me) patient, previously shown to be unable to react against the autologous tumor (Me 28) after mixed lymphocyte‐tumor culture (MLTC), were cultured __in vitro__ with the autologous tumor in MLTC and/or with IL‐2‐containing supernatants

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The study of specific immunity in human cancers has been hampered by the elusive distribution and heterogeneity of effector cells. In this study, we have investigated the distribution of autologous melanoma-specific cytotoxic T lymphocytes (CTLs) in 18 different distant metastases from melanomas (9