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CloN6, a Novel Methyltransferase Catalyzing the Methylation of the Pyrrole-2-carboxyl Moiety of Clorobiocin.

✍ Scribed by Lucia Westrich; Lutz Heide; Shu-Ming Li

Publisher
John Wiley and Sons
Year
2003
Weight
50 KB
Volume
34
Category
Article
ISSN
0931-7597

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O-Alkylation of N-hydroxycarbamate 6 with iodo ester 5 affords 15, which was elaborated to mesylate 4. Intramolecular N-alkylation affords methyl N-Boc-4-methyl-1,2-oxazetidine-4-carboxylate (3). The geminal coupling constant of the methylene protons is 8.5 Hz, which is much smaller than the 12.0 Hz