Biosynthesis of clorobiocin: investigation of the transfer and methylation of the pyrrolyl-2-carboxyl moiety
β Scribed by Christine Anderle; Silke Alt; Tanja Gulder; Gerhard Bringmann; Bernd Kammerer; Bertolt Gust; Lutz Heide
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 559 KB
- Volume
- 187
- Category
- Article
- ISSN
- 0302-8933
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract __The aminocoumarin antibiotic clorobiocin contains a 5βmethylpyrroleβ2βcarboxylic acid unit. This pyrrole unit is derived from Lβproline, and it would be expected that its 5βmethyl group should be introduced by a methylation reaction. However, sequence analysis of the clorobiocin biosy
O-Alkylation of N-hydroxycarbamate 6 with iodo ester 5 affords 15, which was elaborated to mesylate 4. Intramolecular N-alkylation affords methyl N-Boc-4-methyl-1,2-oxazetidine-4-carboxylate (3). The geminal coupling constant of the methylene protons is 8.5 Hz, which is much smaller than the 12.0 Hz