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clk-1, mitochondria, and physiological rates

✍ Scribed by Robyn Branicky; Claire Bénard; Siegfried Hekimi

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
293 KB
Volume
22
Category
Article
ISSN
0265-9247

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✦ Synopsis

Mutations in the C. elegans maternal-effect gene clk-1 are highly pleiotropic, affecting the duration of diverse developmental and behavioral processes. They result in an average slowing of embryonic and post-embryonic development, adult rhythmic behaviors, reproduction, and aging. (1) CLK-1 is a highly conserved mitochondrial protein, (2,3) but even severe clk-1 mutations affect mitochondrial respiration only slightly. (3) Here, we review the evidence supporting the regulatory role of clk-1 in physiological timing. We also discuss possible models for the action of CLK-1, in particular, one proposing that CLK-1 is involved in the coordination of mitochondrial and nuclear function.

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