Clinicopathological significance of MAML2 gene split in mucoepidermoid carcinoma
✍ Scribed by Noda, Haruna; Okumura, Yoshihide; Nakayama, Takahisa; Miyabe, Satoru; Fujiyoshi, Yukio; Hattori, Hideo; Shimozato, Kazuo; Inagaki, Hiroshi
- Book ID
- 119827184
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 626 KB
- Volume
- 104
- Category
- Article
- ISSN
- 1347-9032
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## Abstract The present study reports for the first time a __CRTC3‐MAML2__ fusion gene in a mucoepidermoid carcinoma, as determined by RT‐PCR and sequencing. We screened a total of 67 formalin‐fixed, paraffin‐embedded mucoepidermoid carcinomas for the presence of chimeric genes. In one of these sam
## Abstract Mucoepidermoid carcinomas (MECs) of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) translocation resulting in a __MECT1__–__MAML2__ fusion in which the CREB‐binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused