## Abstract We analyzed 55 primary salivary gland tumors including 22 mucoepidermoid carcinomas (MECs) to determine the association of __MECT1/TORC1/CRTC1βMAML2__ fusion transcript to tumor types, level of MEC differentiation and clinicopathologic parameters. Our primary salivary gland tumors were
A Study of MECT1-MAML2 in Mucoepidermoid Carcinoma and Warthin's Tumor of Salivary Glands
β Scribed by Martins, Carmo; Cavaco, Branca; Tonon, Giovanni; Kaye, Frederic J.; Soares, Jorge; Fonseca, Isabel
- Book ID
- 122279638
- Publisher
- American Society for Investigative Pathology
- Year
- 2004
- Tongue
- English
- Weight
- 830 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1525-1578
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## Abstract Translocations and gene fusions have an important early role in tumorigenesis. The t(11;19) translocation and its __CRTC1/MAML2__ fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the de
Forty-six cases of mucoepidermoid carcinoma (MEC) of the salivary glands were reviewed with an emphasis on the clinicopathologic aspects and prognosis of the tumors. MEC occurred in a wide age range, with few cases being diagnosed in childhood. Its peak of incidence was in the fifth decade and it in