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Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer

✍ Scribed by Takahashi, Naoki; Yamada, Yasuhide; Taniguchi, Hirokazu; Fukahori, Masaru; Sasaki, Yusuke; Shoji, Hirokazu; Honma, Yoshitaka; Iwasa, Satoru; Takashima, Atsuo; Kato, Ken; Hamaguchi, Tetsuya; Shimada, Yasuhiro


Book ID
125403293
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
200 KB
Volume
7
Category
Article
ISSN
1756-0500

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## Abstract Mutational analysis of __KRAS__ codons 12 and 13 is standard for patients with metastatic colorectal cancer since mutations in these codons predict lack of response to anti‐EGFR therapies. However, even among patients whose tumors are wildtype for __KRAS__ codons 12 and 13, only a subse