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Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers

โœ Scribed by Riadh Ben Gacem; Mohamed Hachana; Sonia Ziadi; Soumaya Ben Abdelkarim; Samir Hidar; Mounir Trimeche

Book ID
119257698
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
682 KB
Volume
43
Category
Article
ISSN
1532-8392

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DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have shown that methylation patterns become abnormal in malignant cells and may contribute to tumorigenesis by improper de novo methylation and silencing of the promoters for