Comparative genomic hybridization (CGH) was used in a retrospective analysis of chromosomal imbalances in frozen primary tumor specimens from 14 endometrial carcinoma patients. Chromosome changes were detected in nine cases (64%), and tumor stage and grade tended to parallel the degree of genomic im
β¦ LIBER β¦
Clinicopathologic insight of simultaneously detected primary endometrial and ovarian carcinomas
β Scribed by Alexandros Rodolakis; Nikolaos Thomakos; Nikolaos Akrivos; Maria Sotiropoulou; Ioannis Ioannidis; Dimitrios Haidopoulos; George Vlachos; Aris Antsaklis
- Book ID
- 106081987
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 256 KB
- Volume
- 285
- Category
- Article
- ISSN
- 0003-9128
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## Abstract Loss of heterozygosity (LOH) at the 3p region is found in up to 50% of epithelial ovarian neoplasms. The von HippelβLindau (VHL) gene at the 3p25 locus is one of the tumorβsuppressor genes located at 3p. The role, if any, of the VHL gene locus is not clear in ovarian carcinogenesis. We