Clinical value of serum squamous cell carcinoma antigen in the management of sinonasal inverted papilloma

✍ Scribed by Ryuji Yasumatsu; Torahiko Nakashima; Muneyuki Masuda; Yuichiro Kuratomi; Hideki Shiratsuchi; Naoya Hirakawa; Kichinobu Tomita; Tomoya Yamamoto; Shizuo Komune

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 93 KB
• Volume: 27
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.20115

✦ Synopsis

Background:

Although sinonasal inverted papilloma (ip) is a rare benign tumor, it has a tendency to recur and is sometimes associated with squamous cell carcinoma (scc). therefore, postoperative long-term follow-up of these patients is recommended. we previously reported that serum scc antigen might be a useful tumor marker for sinonasal ip. in this study, we investigated whether serum scc antigen level has a correlation with disease status and is useful in the early detection of recurrent disease.

Methods:

Blood samples for the analysis of serum scc antigen were taken from 28 ip patients before and after surgical treatment.

Results:

Twenty-five (89%) of 28 cases showed evaluated serum scc antigen levels above the upper limit. this marker level decreased in all cases after surgical resection. four of these patients had a recurrence. none of the patients with recurrent tumor showed symptoms at the time of detection of their recurrent tumor, and recurrence was discovered from elevated levels of scc antigen.

Conclusions:

Serum scc antigen level has a correlation with disease status of ip and has a potential to serve as a useful tool for monitoring the course of disease. scc antigen is a reliable tumor marker in the management of sinonasal ips.