Clinical utility of the flow cytometric technique for shared rheumatoid epitope
β Scribed by S. Hedger; R. A. Geddes; L. Wheatland; P. Macardle; M. D. Smith; M. J. Ahern; P. J. Roberts-Thomson
- Book ID
- 106008694
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 90 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0172-8172
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## Abstract ## Objective To study the frequency of allele A of polymorphism PDβ1.3 of the __PDCD1__ gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles. ## Methods A total of 1,175 patients with RA a
Susceptibility to rheumatoid arthritis (RA) maps to residues QKRAA/QRRAA in the third hypervariable region of the HLA DRI31 chain. Peptides from the same area of MHC class II molecules are able to modulate the T-cell repertoire by deleting self-reactive T-cells. The Epstein Barr virus glycoprotein g