Association of HLA–Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the “shared epitope” hypothesis
✍ Scribed by Robert F. Willkens; Gerald T. Nepom; Cara R. Marks; James W. Nettles; Arbara S. Nepom
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 500 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To study the frequency of allele A of polymorphism PD‐1.3 of the __PDCD1__ gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles. ## Methods A total of 1,175 patients with RA a
Objective. In Northern Europeans, rheumatoid arthritis (RA) is strongly associated with a relatively conserved pentapeptide sequence of HLA-DRP found notably in the HLA-DR4 subtypes Dw4 and Dw14 and in DRl. A previous serologic study of HLA class I1 polymorphism in a Greek population with RA failed