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Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer

✍ Scribed by Takanobu Yoshida; Eiji Araki; Masaaki Iigo; Takahiro Fujii; Mitsuya Yoshino; Yasuhiro Shimada; Daizo Saito; Hisao Tajiri; Hajime Yamaguchi; Shigeaki Yoshida; Masahiro Yoshino; Hisanao Ohkura; Masayoshi Yoshimori; Nobuo Okazaki


Publisher
Springer
Year
1990
Tongue
English
Weight
306 KB
Volume
26
Category
Article
ISSN
0344-5704

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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer