Microsatellite instability has been found preferentially in tumours associated with the hereditary non-polyposiscolorectal-cancer (HNPCC) syndrome. This phenotype, manifested as new alleles at microsatellite loci, and often the result of a defective mismatch-repair gene, is seen as allelic mobility
Clinical significance of microsatellite instability in endometrial carcinoma
β Scribed by Jack B. Basil; Paul J. Goodfellow; Janet S. Rader; David G. Mutch; Thomas J. Herzog
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 99 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0008-543X
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## Background: Microsatellite instability (mi) is a frequent occurrence in endometrioid carcinoma of the endometrium (ec). several genes known to contain mononucleotide short tracts in their coding sequences (tgf-beta rii, igfiir, bax, hmsh6, and hmsh3) are likely targets for mutations in these tum
Microsatellite instability (MSI) has been reported to occur in a wide variety of sporadic tumours, such as colorectal and gastric cancers. MSI positivity has been associated with a particular clinico-pathologic profile, including the presence of abundant lymphoid infiltration, poor differentiation a