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Clinical results of two different dose regimens with high-dose interferon-alpha and interleukin-2 in advanced renal cell cancer and malignant melanoma

✍ Scribed by K. Fenchel; A. Winkler; PS. Mitrou; D. Hoelzer; L. Bergmann


Book ID
116167801
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
112 KB
Volume
31
Category
Article
ISSN
0959-8049

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Preclinical data suggest synergy of interleukin-2 (IL-2) combined with alphainterferon (IFN). In addition, toxicities of IL-2 may be decreased by intermittent continuous infusion. The purpose of this trial was to determine the maximum tolerated dose (MTD) of recombinant IL-2 combined with alpha-IFN