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Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients

✍ Scribed by B. Miljković; M. Pokrajac; I. Timotijević; V. Varagić


Book ID
113006500
Publisher
Springer-Verlag
Year
1996
Tongue
English
Weight
449 KB
Volume
21
Category
Article
ISSN
0378-7966

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Five elderly depressed patients were treated with amitriptyline (AT) and nortriptyline (NT) in turn, in a crossover design. Steady-state plasma drug levels were compared with those calculated for eight healthy subjects of previous single-dose studies. Plasma clearances were on average about 2.5 time