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Clinical relevance of the homologous recombination machinery in cancer therapy

✍ Scribed by Kiyoshi Miyagawa


Book ID
108584039
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
162 KB
Volume
99
Category
Article
ISSN
1347-9032

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XRCC2 and XRCC3 proteins are structurally and functionally related to RAD51 which play an important role in the homologous recombination, the process frequently involved in cancer transformation. In our previous work we show that the 135G>C polymorphism (rs1801320) of the __RAD51__ gene can modify t