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Clinical Relevance of Circulating Nucleosomes in Cancer

✍ Scribed by Stefan Holdenrieder; Dorothea Nagel; Andreas Schalhorn; Volker Heinemann; Ralf Wilkowski; Joachim Von Pawel; Hannelore Raith; Knut Feldmann; Andreas E. Kremer; Susanne Müller; Sandra Geiger; Gerhard F. Hamann; Dietrich Seidel; Petra Stieber

Book ID: 111484872
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 235 KB
Volume: 1137
Category: Article
ISSN: 0890-6564
DOI: 10.1196/annals.1448.012

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## Abstract It is known that cell‐free DNA circulates in plasma/serum of patients with cancer and that part of this DNA circulates as nucleosomes that can be quantified by ELISA. We analyzed the effect of tumor and chemotherapy upon the levels of nucleosomes __in vitro__, __in vivo__ and in cervica