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Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin–1 gene

✍ Scribed by A. J. Larner; M. Doran


Publisher
Springer
Year
2005
Tongue
English
Weight
337 KB
Volume
253
Category
Article
ISSN
0340-5354

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Many different mutations that cause Alzheimer's disease (AD) have been found in the presenilin-1 gene (PSEN1) and are associated with the most aggressive forms of the disease. With the aim of screening for PSEN1 genetic variations, we developed a method based on denaturing gradient gel electrophores