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Clinical pharmacokinetics of ketobemidone. Its bioavailability after rectal administration

✍ Scribed by P. Anderson; S. Arnér; U. Bondesson; L. O. Boréus; P. Hartvig


Publisher
Springer
Year
1981
Tongue
English
Weight
689 KB
Volume
19
Category
Article
ISSN
0031-6970

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The pharmacokinetic properties of hydromorphone in healthy young male subjects were studied after i.v., peroral, and rectal administration. After i.v. administration the following pharmacokinetic parameters were found: elimination half-life 2.36 k 0.5 h, hepatic extraction ratio 0.51, apparent volum