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Pharmacokinetics of hydromorphone after intravenous, peroral and rectal administration to human subjects

✍ Scribed by P. V. Parab; Dr. W. A. Ritschel; D. E. Coyle; R. V. Gregg; D. D. Denson

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
629 KB
Volume
9
Category
Article
ISSN
0142-2782

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✦ Synopsis

The pharmacokinetic properties of hydromorphone in healthy young male subjects were studied after i.v., peroral, and rectal administration. After i.v. administration the following pharmacokinetic parameters were found: elimination half-life 2.36 k 0.5 h, hepatic extraction ratio 0.51, apparent volume of distribution 2.9 f 1.3 L kg-' and volume of central compartment 0.23 k 0.2 L kg-'. The absolute bioavailability after peroral administration was 50.7 rt 29.8 per cent, and that after rectal administration was 33 k 22 per cent.

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