Clinical pharmacokinetics of 6-hour infusion of high-dose methotrexate. Preliminary trial of monitoring high infusion doses
β Scribed by M. Luyckx; J. L. Cazin; C. Brunet; P. Gosselin; M. C. Demaille
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 715 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0031-6970
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A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtaine
## Abstract Plasma methotrexate (MTX) concentrations were quantitated in 34 patients after 127 highβdose (35β350 mg/kg) infusions with citrovorum factor rescue. Significant linear correlations have been obtained between methotrexate dosage and concentrations in plasma at 6 and 24 hours after the in
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