The pharmacokinetics of tamsulosin (TAM) was investigated using male Sprague-Dawley rats in which plasma ␣ 1 -acid glycoprotein (␣ 1 -AGP) levels were elevated by the subcutaneous injection of 0.2 mL/kg of turpentine oil. ␣ 1 -AGP levels increased about eight times after turpentine oil treatment, ca
Pharmacokinetics and toxicity of high-dose human α1-acid glycoprotein infusion in the rat
✍ Scribed by D. E. Keyler; P. R. Pentel; D. B. Haughey
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 398 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Methadone is a basic drug highly bound to a1-acid glycoprotein (AGP), a plasma protein that increases in several pathological situations. Our aims were to evaluate the processes (pharmacokinetics-PK and/or pharmacodynamics-PD) associated with changes of methadone analgesia under conditions of increa
## BACKGROUND. A receptor for a,-acid glycoprotein glycoforms AGP-8 and AGP-C in the epithelium of the rat prostate gland and seminal vesicles is described. ## METHODS. The interaction between AGP-glycoforms and their receptor is a lectin-like interaction confirmed by inhibition of the binding
The transport of human aI-acid glycoprotein from the circulation to the bile has been studied in the rat. Biliary excretion was proportional to the i.v. injected dose, and the percentage excreted remained constant. The amount excreted in the bile (over 4 hr) was inversely related to the rate of hepa