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Clinical perspectives of granulocyte transfusions: Efficacy to date

โœ Scribed by Ronald G. Strauss

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
445 KB
Volume
10
Category
Article
ISSN
0733-2459

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โœฆ Synopsis

The literature pertaining to the use of granulocyte transfusions as treatment for progressive bacterial, yeast, and fungal infections in severely neutropenic patients is reviewed. Efficacy in treating bacterial infections that are unresponsive to antimicrobial therapy is well established--especially if bone marrow failure does not recover rapidly and neutropenia is persistent. The role of therapeutic granulocyte transfusions for yeast and fungal infections has potential merit, but current data are incomplete and findings are inconsistent. The possibility of greater success has been raised by use of recombinant granulocyte colony stimulating factor to greatly increase the yield of neutrophils collected from normal donors.

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