The literature pertaining to the use of granulocyte transfusions as treatment for progressive bacterial, yeast, and fungal infections in severely neutropenic patients is reviewed. Efficacy in treating bacterial infections that are unresponsive to antimicrobial therapy is well established--especially
Blood center perspective of granulocyte transfusions: Future applications
β Scribed by Thomas H. Price
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 471 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0733-2459
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β¦ Synopsis
The role of the blood bank in provision of an optimal granulocyte concentrate is discussed. The importance of the granulocyte dose is emphasized, and recent developments permitting the collection of larger numbers of cells are reviewed. In particular, the administration of granulocyte colony-stimulating factor to normal donors has been reported to result in dramatically increased neutrophil yields. Recent data has also suggested that increased efficiencies of collection can he realized by the use of hetastarch as the red cell sedimenting agent. o 1995 ~i l e y -~i s a , Inc
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