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Clinical Implications of the Colorectal Cancer Risk Associated With MUTYH Mutation

✍ Scribed by Lubbe, S. J.; Di Bernardo, M. C.; Chandler, I. P.; Houlston, R. S.

Book ID
111934235
Publisher
American Society of Clinical Oncology
Year
2009
Tongue
English
Weight
134 KB
Volume
27
Category
Article
ISSN
0732-183X

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πŸ“œ SIMILAR VOLUMES

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## Abstract Cancer risks for a person who has inherited a __MUTYH__ mutation from only one parent (monoallelic mutation carrier) are uncertain. Using the Colon Cancer Family Registry and Newfoundland Familial Colon Cancer Registry, we identified 2,179 first‐ and second‐degree relatives of 144 incid

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## Abstract The __MutYH__ gene is an adenine‐specific DNA glycosylase that prevents G/T transversions. Germline mutation in this gene causes __MYH__‐associated polyposis (MAP) that predispose to hereditary colorectal cancer (CRC). This study describes for the first time the association of the __Mut