Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia
✍ Scribed by Oliver Galm; Stefan Wilop; Christian Lüders; Edgar Jost; Gerald Gehbauer; James G. Herman; Rainhardt Osieka
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 295 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0939-5555
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## Abstract ## BACKGROUND Aberrant methylation of promoter‐associated cystosine‐guanine (CpG) islands is an epigenetic modification of DNA frequently observed in adult patients with acute lymphocytic leukemia (ALL). This epigenetic modification has been associated with gene silencing, malignant tr
## Abstract Hypermethylator phenotype, a propensity of tumors to incur nonrandom concurrent methylation, has been described in several tumors, including acute myeloid leukemia (AML). More recent studies identified methylation of other tumor suppressor genes, DAP‐kinase and SOCS1, singly in AML. We