✦ LIBER ✦

Clinical impact of chromosome I aberrations in neuroblastoma: A metaphase and interphase cytogenetic study

✍ Scribed by Holger Christiansen; Joachim Schestag; Nina M. Christiansen; Karl-Heinz Grzeschik; Prof. Dr. Fritz Lampert

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 737 KB
Volume: 5
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870050208

No coin nor oath required. For personal study only.

✦ Synopsis

Neuroblastoma tumors are characterized by aberrations of chromosome I. Rapid detection of these chromosomal aberrations at diagnosis could give important clues t o outcome and therapy. W e attempted t o detect numerical and structural aberrations of chromosome I not only by classical metaphase cytogenetics but also by interphase cytogenetics in order t o overcome difficulties of karyotyping due t o diminished metaphase quality and quantity in primary neuroblastoma samples. Karyotypic changes of chromosome I in 53 primary neuroblastomas were evaluated. In addition, we successfully performed interphase cytogenetics using single and double in situ hybridization procedures with chromosome I -specific repetitive D N A probes on nuclei preparations obtained from 46 and 20 tumors, respectively. Polysomies of structurally normal chromosomes I were predominantly seen in tumors with good prognosis, whereas deletions of I p material were nearly exclusively confined t o progressive tumors. Numerical and structural chromosome I aberrations as studied by metaphase and interphase cytogenetics are thus valuable prognostic markers in neuroblastoma. Genes Chrom Cancer 5 : / 4 / -/ 4 9 (1992).

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