The c-met protooncogene is a growth factor receptor with tyrosine kinase activity. Recently the hepatocyte growth factor was identified as the ligand for this receptor. Because the hepatocyte growth factor is a most potent mitogen in hepatocytes, possible involvement of c-met expression in hepatocar
Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma
โ Scribed by Kondo, Shunsuke; Ojima, Hidenori; Tsuda, Hitoshi; Hashimoto, Jun; Morizane, Chigusa; Ikeda, Masafumi; Ueno, Hideki; Tamura, Kenji; Shimada, Kazuaki; Kanai, Yae; Okusaka, Takuji
- Book ID
- 125813199
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 505 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1341-9625
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The c-met proto-oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF), a potent mitogen and motogen for epithelial cells. Because of its profound effects on cell growth and motility, HGF may be important in the development of cancer metastases in hepatocellular carcinoma (
mal and malignant epithelial cells and several other cell The c-met proto-oncogene encodes the tyrosine kinase types, including endothelial cells and melanocytes. 4,5 receptor for hepatocyte growth factor (HGF), a potent It has been reported that the expression of c-Met is enmitogen and motogen for