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Clinical, Genetic, and Biochemical Findings in Two Siblings With Papillon-Lefèvre Syndrome

✍ Scribed by Cagli, N. Arzu; Hakki, Sema S.; Dursun, Recep; Toy, Hatice; Gokalp, Alparslan; Ryu, Ok Hee; Hart, P. Suzanne; Hart, Thomas C.


Book ID
126976466
Publisher
American Academy of Periodontology
Year
2005
Tongue
English
Weight
297 KB
Volume
76
Category
Article
ISSN
0022-3492

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Papillon Lefèvre syndrome (PLS) is an autosomal recessive disorder characterized by palmoplantar hyperkeratosis and severe periodontitis. The disease is caused by mutations in the cathepsin C gene (CTSC) that maps to chromosome 11q14. CTSC gene mutations associated with PLS have been correlated with